Make a Donation  |  Site Map  |  Contact Us

LABORATORY OF CELL CYCLE REGULATION & MOLECULAR ONCOLOGY

Dr. S. KANNAN, M.Sc., Ph.D.

OVERVIEW :

Cancers of the oral cavity are the 6th most common cancer worldwide. In India, oral cancer tops the chart among male cancers and ranks third among women. The mandate of our lab is to decipher the basic molecular mechanisms underlying oral cancer development thereby enabling better diagnosis and treatment of the disease. Cell cycle regulatory genes are frequently dysregulated in cancer. The analysis of the cell cycle revealed p53, p16 and cyclin D1 as good biomarkers for predicting prognosis in oral carcinoma. In our proteomic approach; we identified several proteins involved in the stabilization of p53 in oral carcinoma. Studies are underway to pinpoint each of these proteins. In addition, analysis of microsatellite markers showed that markers encompassing p16 gene associated with oral cancer progression. Currently we are also analyzing cell cycle regulatory genes at the transcriptome level using TLDA. Studies on Micro RNA profiling using Micro array of oral carcinoma is also being undertaken in order to reveal molecular mechanisms behind oral carcinogenesis.

SELECTED PUBLICATIONS:

1. KM Sathyan, KR Nalinakumari, Thomas Abraham and S Kannan. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. Oral. Oncol (2007), doi:10.1016/j.oraloncology.2007.09.003.
2. R Sailasree, A Abhilash, KM Sathyan, KR Nalinakumari, Shaji Thomas and S Kannan. Differential roles of p16INK4A and p14ARF genes in predicting disease recurrence in oral carcinoma. Cancer Epidemiol Biomarkers Prev. 17:414-420, 2007.
3. KM Sathyan, KR Nalinakumari and S Kannan. H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma. Mod Pathol. 20: 1141-8 2007.
4. KM Sathyan, R Sailasree, R Jayasurya, K Lakshminarayanan, Thomas Abraham, KR Nalinakumari, Elizabeth K Abraham and S Kannan: Carcinoma of tongue and the buccal mucosa represent different biological subentities of the oral carcinoma. J Cancer Res Clin Oncol, 132: 601-609, 2006.
5. R Jayasurya, KM Sathyan, K Lakshminarayanan, Thomas Abrham, KR Nalinakumari, Elizabeth K Abraham, M Krishnan Nair and S Kannan: Phenotypic alterations in Rb pathway have more prognostic influence than p53 pathway proteins in oral carcinoma. Modern Pathol, 18: 1056-1066, 2005.
6. R Jayasurya, G Francis, S Kannan, K Lekshminarayanan, KR Nalinakumari, T Abraham, E K Abraham, M K Nair. p53, p16, and cyclin D1 : Molecular determinants of radiotherapy treatment response in oral carcinoma. Int J Cancer,109: 710-716, 2004.
7. S Kannan, H Yolozaki, K Jayasree, P Sebastian, A Mathews, E K Abraham, M K Nair, E Tahara. Infrequent loss of heterozygosity of the major tumor suppressor genes in oral squamous cell carcinoma: analysis by PCR-RFLP and mirosatellite assay. Int J Oral Maxillofaci Surg, 2001.
8. S Kannan, H Tahara, H Yokozaki, B Mathew, KR Nalinakumari,MK Nair, E Tahara. Telomerase activity in premalignant and malignant lesions of human oral mucosa. Cancer Epidemiol Biomarkers Prev, 6: 413-420, 1997.
9. S Kannan, P Balaram, R Pillai GJ Chandran, MK Nair. Immunohistochemical analysis of ras p21 expression in normal, premalignant and malignant oral mucosa. Int J Cancer, 55: 700-702, 1993.
10. R Pillai, P Balaram, S Kannan. Immunological abnormalities in oral precancers. Cancer Letters, 57:1-6, 1991.

Lab Members:

Group Photo

Ph. D. Students :

1. Abitha Murali
   Research Scholar
   E mail: abithamurali@gmail.com
2. Deepak Roshan V. G.
   Research Scholar
   E mail: deepakroshanvg@gmail.com
3. Dileep Kumar U.
   Research Scholar
   E mail: dileepbiotech@yahoo.co.in
   

Alumni

1. Dr. Jayasurya R.
2. Dr. Sathyan K. M.
   E mail: sathyanrcc@gmail.com
3. Mr.Geo Francis
   E mail: geoflip@yahoo.co.in
4. Mr. Abhilash A.
   E mail: abhilashashok@yahoo.co.in
5. Ms. Sailasree R.
   E mail: sailarcc@gmail.com