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LABORATORY OF CYTOGENETICS &
MOLECULAR DIAGNOSTICS

Dr. RAVINDRAN ANKATHIL, M.Sc., Ph.D.

Brief overview of current research:

Molecular Genetic Analysis BRCA2 gene mutations and Pathology in Hereditary Breast and Ovarian Cancer.
.Genetic Susceptibility Studies in Lung Cancer.
Germline Mutation Analysis of Mismatch Repair Genes in Familial Colorectal Cancer Patients.
Role of Germline Polymorphisms of Few Low Penetrance Genes in Familial Breast Cancer.
Genetics of Colorectal Cancer Susceptibility.

Existing Projects:

1. Genetic Susceptibility Studies in Lung Cancer (From January 2006 – December 2008) Funded by Dept. of Science and Technology, Govt. of India.

Dr. HARIHARAN S, M.Sc., Ph.D.

Brief Overview of Current Research

Cytogenetic and Molecular Genetic Studies of abnormalities in patients with Acute and Chronic Myeloid Leukemias.

Selected Publications

1. Sreeja L, Syamala V, Raveendran PB, Santhi S, Madhavan J, Ravindran Ankathil. p53 Arg72Pro Polymorphism Predicts Survival Outcome in Lung Cancer Patients in Indian Population. Cancer Investigation. 2007 (In press)
2. Syamala VS, Sreeja L, Syamala V, Raveendran PB, Balakrishnan R, Kuttan R, Ravindran Ankathil. Influence of germline polymorphisms of GSTT1, GSTM1, and GSTP1 in familial versus sporadic breast cancer susceptibility and survival. Familial Cancer, 2007 Dec 14; [Epub ahead of print]
3. Sreeja L, Syamala VS, Syamala V, Hariharan S, Raveendran PB, Vijayalekshmi RV, Madhavan J, Ankathil R. Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India. J Cancer Res Clin Oncol. 2007 Oct 19; [Epub ahead of print]
4. Vinodkumar B, Syamala V, Abraham EK, Balakrishnan R, Ankathil R. Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India. J Exp Clin Cancer Res. 26: 329-36, 2007.
5. Azman BZ, Ankathil R, Siti Mariam I, Suhaida MA, Norhashimah M, Tarmizi AB, Nor Atifah MA, Kannan TP, Zilfalil BA. Cytogenetic and clinical profile of Down syndrome in Northeast Malaysia. Singapore Med J. 48: 550-4, 2007.
6. Syamala V, Sreeja L, Syamala VS, Vinodkumar B, Raveendran PB, Sreedharan H, Kuttappan R, Balakrishnan L, Ankathil R. Novel germline mutations in BRCA2 gene among 96 hereditary breast and breast-ovarian cancer families from Kerala, South India. J Cancer Res Clin Oncol. 133: 867-74, 2007.
7. Sunil SK, Prakash PN, Hariharan S, Vinod G, Preethi RT, Geetha N, Ankathil R. Adult acute lymphoblastic leukemia with near haploidy, hyperdiploidy and Ph positive lines: a rare entity with poor prognosis. Leuk Lymphoma. 47: 561-3, 2006.
8. Sreeja L, Syamala V, Hariharan S, Madhavan J, Devan SC, Ankathil R. Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. J Hum Genet. 50: 618-27, 2005.
9. Kumar BV, Lakhotia S, Ankathil R, Madhavan J, Jayaprakash PG, Nair MK, Somasundaram K. Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families. Cancer Biol Ther. 1: 18-21, 2002.
10. Jyothish B, Ravindran Ankathil, Chandini R, Vinod Kumar B, Sunil Nayar G, Dinesh Roy D, Jayaprakash Madhavan, Krishnan Nair M : DNA repair proficiency : a potential marker for identification of high risk members in breast cancer families. Cancer Letters 124: 9-13, 1998.
11. Ravindran Ankathil, Bhattathiri VN, James V. Francis, Ratheesan K, Jyothish B, Chandini R, Dinesh Roy, Elizabeth Abraham, Krishnan Nair M. Mutagen sensitivity as a predisposing factor in familial oral cancer. Int. J Cancer. Pred Oncol 69: 265-267, 1996.
    

Lab Members

Project Assistant

Ms. Santhi S santhisanju@yahoo.com

Ph. D Students:

Alumni