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LABORATORY
OF STEM CELL BIOLOGY
Dr.
KM SATHYAN, M.Sc. Ph.D.
Brief Overview of Research
We are interested in elucidating the basic
biology of stem cells. The specific alterations that lead
to the formation of cancer stem cells and differences in the
biology of cancer stem cells and normal stem cell are the
major focus. This may lead to development of new drugs, which
could directly target cancer stem cells. We are also reevaluating
stem cell associated genes as prognostic biomarker in oral
carcinoma.
Existing Projects
‘Molecular dissection of TGFß-Smad signaling
pathway in oral carcinoma’
Fast track grant for Young Scientists, DST, Govt. of India.
Selected Publications
- Sathyan KM, Nalinakumari KR, Thomas Abraham and Kannan
S. CCND1 polymorphisms (A870G and C1722G) modulate its protein
expression and survival in oral carcinoma. Oral Oncol (2007),
doi:10.1016/j.oraloncology.2007.09.003.
- Sailasree R, Abhilash A, Sathyan KM, Nalinakumari KR,
Shaji Thomas and Kannan S. Differential roles of p16INK4A
and p14ARF genes in predicting disease recurrence in oral
carcinoma. Cancer Epidemiol Biomarkers Prev. 17: 414-420,
2007.
- Sathyan KM, Nalinakumari KR and Kannan S. H-Ras mutation
modulates the expression of major cell cycle regulatory
proteins and disease prognosis in oral carcinoma. Mod Pathol.
20: 1141-8 2007.
- Sathyan KM, Nalinakumari KR, Thomas Abraham and Kannan
S. Influence of single nucleotide polymorphisms in H-Ras
and cyclin D1 genes on oral cancer susceptibility. Oral
Oncol, 42: 607-613, 2006.
- Sathyan KM, Sailasree R, Jayasurya R, Lakshminarayanan
K, Thomas Abraham, Nalinakumari KR, Elizabeth K Abraham
and Kannan S. Carcinoma of tongue and the buccal mucosa
represent different biological subentities of the oral carcinoma.
J Cancer Res Clin Oncol, 132: 601-609, 2006.
- Jayasurya R, Sathyan KM, Lakshminarayanan K, Thomas Abraham,
Nalinakumari KR, Elizabeth K Abraham, Krishnan Nair M and
Kannan S. Phenotypic alterations in Rb pathway have more
prognostic influence than p53.
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