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LABORATORY OF BIOPHARMACEUTICALS

Dr.T.T. SREELEKHA, M.Sc., Ph.D.

Brief overview of current research:

We are working on biological activities of plant polysaccharides. We have isolated three different polysaccharides with immunomodulatory and antiproliferative activities. One of the polysaccharide was found to have a metaphase arresting property like colchicines. Further studies of the mechanism of action of these polysaccharides as anticancer and immunomodulatory agents are progressing and the results obtained are promising. Elucidation of the mechanisms of action of the active principles is highly inevitable in drug development programs for which gene profiling by micro array is an excellent technology and we are planning to incorporate such tools in our future work.

Existing Projects:

1. Polysaccharides from Tamarindus indica as inhibitors of mitotic progression in malignant cell lines – elucidation of the target protein (Funded by KSCSTE)
2. Genomic instability in lung cancer as an early cancer prediction tool (Funded by DST)

Lab Members

Ph. D Students:

1. Aravind. S.R M.Sc. Microbiology aravind_sr2003@yahoo.co.in
2. Baby Prathap, M.Phil. Biochemistry adoorprathap@gmail.com
3. Rajesh.M, M. Sc. Biotechnology rmnair2000@yahoo.com

Selected Publications

1. Sreelekha TT, Nair MK, Jayaprakash PG and Pillai MR. Mutant ras p21 profile and early tumour response to radiotherapy in cancer of the uterine cervix. J Exp and Clin Cancer Res 18: 337-341, 1999.
2. Sreelekha TT, Pradeep VM, Vijayalakshmi K, Belthazar A, Chellam VG, Nair MB and Pillai MR. In situ apoptosis in the thyroid. Thyroid 10 (2): 117-122, 2000.
3. Sreelekha TT, Jayaprakash Madhavan, Nair MK and Pillai MR. Ras gene mutation and programmed cell death in rectal carcinoma. GI Cancer 3 (4): 269-279, 2000.
4. Sreelekha TT, Ramadas K, Pandey M, Thomas G, Nalinakumari KR, Pillai MR. Genetic polymorphism of CYP1 A1, GST M1 and GSTT1 genes in Indian oral cancer. Oral Oncol. 37, 593-598, 2001.
5. Berlin Grace VM, Shalini JV, Sreelekha TT, Devaraj SN, Devaraj H. Co-over expression of p53 and bcl-2 proteins in HPV – induced squamous cell carcinoma of the uterine cervix. Gynaecologic Oncology 91, 51-58, 2003.
6. Nair PKK, Sreelekha TT, Hareendran NK, Nair MK. Environmental Cancer – A Perspective. In Environmental pollution and Management. Ed. Trivedi PC, Avishkar Publishers, Distributers, Jaipur, India. 243-269, 2004.
7. Balaram P, Krishna SM, James S, Cherian VT, Sreelekha TT, Mathew A. Epstein-Bar virus down regulates expression of DNA-double strand break repair proteins in nasopharyngeal cancer. Gene Therapy and Molecular Biology 10, 123-132, 2006.
8. Sreelekha TT, Balaram P, Nair PKK. Biodiversity - in Phytochemical Research and development. In "Biodiversity in Indian Scenarios”. Ed. Ramakrishnan N, Daya Publishing House, Delhi, India, Chapter 2, 23 – 33, 2006.